LHFPL tetraspan subfamily member 5 protein (LHFPL5)

About LHFPL tetraspan subfamily member 5 protein

LHFPL tetraspan subfamily member 5 protein (LHFPL5) is a protein from Homo sapiens identified by UniProt accession Q8TAF8, 219 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.

Target properties

Protein name	LHFPL tetraspan subfamily member 5 protein
UniProt accession	Q8TAF8
Gene	LHFPL5
Organism	Homo sapiens
Length	219 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (57)

Diseases linked to this target (Open Targets).

deafness · score 0.66
hearing loss, autosomal recessive · score 0.63
nonsyndromic genetic hearing loss · score 0.40
mean corpuscular volume · score 0.34
autosomal recessive non-syndromic intellectual disability · score 0.34
mean reticulocyte volume · score 0.30
mean corpuscular hemoglobin concentration · score 0.30
Hearing impairment · score 0.30
arthritis · score 0.28
Immature Reticulocyte Fraction Measurement · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TAF8-F1	alphafold	PREDICTED	89.18	—

Amino-acid sequence (219 residues)

MVKLLPAQEA AKIYHTNYVR NSRAVGVMWG TLTICFSVLV MALFIQPYWI GDSVNTPQAG YFGLFSYCVG NVLSSELICK GGPLDFSSIP SRAFKTAMFF VALGMFLIIG SIICFSLFFI CNTATVYKIC AWMQLAAATG LMIGCLVYPD GWDSSEVRRM CGEQTGKYTL GHCTIRWAFM LAILSIGDAL ILSFLAFVLG YRQDKLLPDD YKADGTEEV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards