V-set and transmembrane domain-containing protein 2A (VSTM2A)

About V-set and transmembrane domain-containing protein 2A

V-set and transmembrane domain-containing protein 2A (VSTM2A) is a protein from Homo sapiens identified by UniProt accession Q8TAG5, 236 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	V-set and transmembrane domain-containing protein 2A
UniProt accession	Q8TAG5
Gene	VSTM2A
Organism	Homo sapiens
Length	236 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.40
COVID-19 · score 0.36
mathematical ability · score 0.36
smoking status measurement · score 0.25
attention deficit hyperactivity disorder · score 0.24
antisocial behaviour measurement · score 0.24
substance abuse · score 0.24
cervical carcinoma · score 0.24
cognitive function measurement · score 0.24
body height · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TAG5-F1	alphafold	PREDICTED	71.13	—

Amino-acid sequence (236 residues)

MMGIFLVYVG FVFFSVLYVQ QGLSSQAKFT EFPRNVTATE GQNVEMSCAF QSGSASVYLE IQWWFLRGPE DLDPGAEGAG AQVELLPDRD PDSDGTKIST VKVQGNDISH KLQISKVRKK DEGLYECRVT DANYGELQEH KAQAYLKVNA NSHARRMQAF EASPMWLQDM KPRKNVSAAI PSSIHGSANQ RTHSTSSPQV VAKIPKQSPQ SGARIATSHG LSVLLLVCGF VKGALL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards