About GTPase RhebL1
GTPase RhebL1 (RHEBL1) is a protein
from Homo sapiens identified by UniProt accession
Q8TAI7, 183 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | GTPase RhebL1 |
|---|
| UniProt accession | Q8TAI7 |
|---|
| Gene | RHEBL1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 183 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.22
- intelligence · score 0.22
- bipolar disorder · score 0.21
- reaction time measurement · score 0.21
- schizophrenia · score 0.15
- heel bone mineral density · score 0.14
- cognitive function measurement · score 0.13
- attention deficit hyperactivity disorder · score 0.13
- age at menarche · score 0.11
- osteoporosis · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TAI7-F1 | alphafold | PREDICTED | 92.90 | — |
Amino-acid sequence (183 residues)
MPLVRYRKVV ILGYRCVGKT SLAHQFVEGE FSEGYDPTVE NTYSKIVTLG KDEFHLHLVD TAGQDEYSIL PYSFIIGVHG YVLVYSVTSL HSFQVIESLY QKLHEGHGKT RVPVVLVGNK ADLSPEREVQ AVEGKKLAES WGATFMESSA RENQLTQGIF TKVIQEIARV ENSYGQERRC HLM
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