GA-binding protein subunit beta-2 (GABPB2)

About GA-binding protein subunit beta-2

GA-binding protein subunit beta-2 (GABPB2) is a protein from Homo sapiens identified by UniProt accession Q8TAK5, 448 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.

Target properties

Protein name	GA-binding protein subunit beta-2
UniProt accession	Q8TAK5
Gene	GABPB2
Organism	Homo sapiens
Length	448 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (87)

Diseases linked to this target (Open Targets).

body height · score 0.19
body mass index · score 0.19
alcohol consumption measurement · score 0.15
age at first sexual intercourse measurement · score 0.12
osteoporosis · score 0.10
age at menarche · score 0.10
appendicular lean mass · score 0.09
skin cancer · score 0.09
non-melanoma skin carcinoma · score 0.09
waist circumference · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TAK5-F1	alphafold	PREDICTED	62.83	—

Amino-acid sequence (448 residues)

MSLVDLGKRL LEAARKGQDD EVRTLMANGA PFTTDWLGTS PLHLAAQYGH YSTAEVLLRA GVSRDARTKV DRTPLHMAAA DGHAHIVELL VRNGADVNAK DMLKMTALHW ATERHHRDVV ELLIKYGADV HAFSKFDKSA FDIALEKNNA EILVILQEAM QNQVNVNPER ANPVTDPVSM AAPFIFTSGE VVNLASLISS TNTKTTSGDP HASTVQFSNS TTSVLATLAA LAEASVPLSN SHRATANTEE IIEGNSVDSS IQQVMGSGGQ RVITIVTDGV PLGNIQTSIP TGGIGQPFIV TVQDGQQVLT VPAGKVAEET VIKEEEEEKL PLTKKPRIGE KTNSVEESKE GNERELLQQQ LQEANRRAQE YRHQLLKKEQ EAEQYRLKLE AIARQQPNGV DFTMVEEVAE VDAVVVTEGE LEERETKVTG SAGTTEPHTR VSMATVSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards