Uncharacterized protein C9orf43 (C9orf43)

About Uncharacterized protein C9orf43

Uncharacterized protein C9orf43 (C9orf43) is a protein from Homo sapiens identified by UniProt accession Q8TAL5, 461 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Protein name	Uncharacterized protein C9orf43
UniProt accession	Q8TAL5
Gene	C9orf43
Organism	Homo sapiens
Length	461 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (62)

Diseases linked to this target (Open Targets).

systolic blood pressure · score 0.38
body height · score 0.23
mean platelet volume · score 0.21
platelet count · score 0.20
hematocrit · score 0.17
red blood cell density measurement · score 0.16
sitting height measurement · score 0.13
hemoglobin measurement · score 0.13
erythrocyte count · score 0.12
Abnormality of refraction · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TAL5-F1	alphafold	PREDICTED	46.63	—

Amino-acid sequence (461 residues)

MDLPDESQWD ETTCGLAVCQ HPQCWATIRR IERGHPRILG SSCKTPLDAE DKLPVLTVVD ILDSGFAAHH LPECTFTKAH SLLSQSSKFY SKFHGRPPKG LPDKSLINCT NRLPKFPVLN LNETQLPCPE DVRNMVVLWI PEETEIHVSQ HGKKKRKNSA VKSKSFLGLS GNQSAGTRVG TPGMIVPPPT PVQLSEQFSS DFLPLWAQSE ALPQDLLKEL LPGGKQTMLC PEMKIKLAMM KKNLPLEKNR PDSVISSKMF LSIHRLTLER PALRYPERLK KLHNLKTEGY RKQQQRQQQQ QQQQKKVKTP IKKQEAKKKA KSDPGIQSTS HKHPVTTVHD RLYGYRTLPG QNSDMKQQQQ MEKGTTSKQD STERPKMNYY DHADFHHSVK SPELYETEPT NKDISAPVDA VPEAQAARQK KISFNFSEIM ASTGWNSELK LLRILQDTDD EDEEDQSSGA E

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards