Protein phosphatase 1 regulatory subunit 35 (PPP1R35)

About Protein phosphatase 1 regulatory subunit 35

Protein phosphatase 1 regulatory subunit 35 (PPP1R35) is a protein from Homo sapiens identified by UniProt accession Q8TAP8, 253 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	Protein phosphatase 1 regulatory subunit 35
UniProt accession	Q8TAP8
Gene	PPP1R35
Organism	Homo sapiens
Length	253 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin concentration · score 0.12
platelet count · score 0.10
heel bone mineral density · score 0.09
self reported educational attainment · score 0.09
platelet crit · score 0.08
serum albumin measurement · score 0.07
platelet component distribution width · score 0.06
monocyte count · score 0.06
hereditary hyperferritinemia with congenital cataracts · score 0.05
Cataract-microcornea syndrome · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TAP8-F1	alphafold	PREDICTED	68.90	—

Amino-acid sequence (253 residues)

MMMGCGESEL KSADGEEAAA VPGPPPEPQV PQLRAPVPEP GLDLSLSPRP DSPQPRHGSP GRRKGRAERR GAARQRRQVR FRLTPPSPVR SEPQPAVPQE LEMPVLKSSL ALGLELRAAA GSHFDAAKAV EEQLRKSFQI RCGLEESVSE GLNVPRSKRL FRDLVSLQVP EEQVLNAALR EKLALLPPQA RAPHPKEPPG PGPDMTILCD PETLFYESPH LTLDGLPPLR LQLRPRPSED TFLMHRTLRR WEA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards