Serine/threonine-protein kinase Kist (UHMK1)

About Serine/threonine-protein kinase Kist

Serine/threonine-protein kinase Kist (UHMK1) is a protein from Homo sapiens identified by UniProt accession Q8TAS1, 419 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	Serine/threonine-protein kinase Kist
UniProt accession	Q8TAS1
Gene	UHMK1
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

Rare genetic intellectual disability with developmental anomaly · score 0.27
neurodegenerative disease · score 0.24
sitting height measurement · score 0.23
lung adenocarcinoma · score 0.09
blood protein measurement · score 0.08
hepatocellular carcinoma · score 0.08
melanoma · score 0.06
schizophrenia · score 0.05
neoplasm · score 0.04
Combined hyperlipidemia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TAS1-F1	alphafold	PREDICTED	89.75	—

Amino-acid sequence (419 residues)

MAGSGCAWGA EPPRFLEAFG RLWQVQSRLG SGSSASVYRV RCCGNPGSPP GALKQFLPPG TTGAAASAAE YGFRKERAAL EQLQGHRNIV TLYGVFTIHF SPNVPSRCLL LELLDVSVSE LLLYSSHQGC SMWMIQHCAR DVLEALAFLH HEGYVHADLK PRNILWSAEN ECFKLIDFGL SFKEGNQDVK YIQTDGYRAP EAELQNCLAQ AGLQSDTECT SAVDLWSLGI ILLEMFSGMK LKHTVRSQEW KANSSAIIDH IFASKAVVNA AIPAYHLRDL IKSMLHDDPS RRIPAEMALC SPFFSIPFAP HIEDLVMLPT PVLRLLNVLD DDYLENEEEY EDVVEDVKEE CQKYGPVVSL LVPKENPGRG QVFVEYANAG DSKAAQKLLT GRMFDGKFVV ATFYPLSAYK RGYLYQTLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards