About Endonuclease 8-like 3
Endonuclease 8-like 3 (NEIL3) is a protein
from Homo sapiens identified by UniProt accession
Q8TAT5, 605 residues long.
MolForge cross-references it against 0 known binders and
99 disease associations.
Target properties
| Protein name | Endonuclease 8-like 3 |
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| UniProt accession | Q8TAT5 |
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| Gene | NEIL3 |
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| Organism | Homo sapiens |
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| Length | 605 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (99)
Diseases linked to this target (Open Targets).
- platelet count · score 0.38
- hypersensitivity reaction disease · score 0.37
- neurofibrillary tangles measurement · score 0.29
- apolipoprotein A 1 measurement · score 0.12
- Low-frequency sensorineural hearing impairment · score 0.12
- hepatocellular carcinoma · score 0.11
- cancer · score 0.10
- neoplasm · score 0.10
- lung adenocarcinoma · score 0.08
- non-small cell lung carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TAT5-F1 | alphafold | PREDICTED | 69.58 | — |
Amino-acid sequence (605 residues)
MVEGPGCTLN GEKIRARVLP GQAVTGVRGS ALRSLQGRAL RLAASTVVVS PQAAALNNDS SQNVLSLFNG YVYSGVETLG KELFMYFGPK ALRIHFGMKG FIMINPLEYK YKNGASPVLE VQLTKDLICF FDSSVELRNS MESQQRIRMM KELDVCSPEF SFLRAESEVK KQKGRMLGDV LMDQNVLPGV GNIIKNEALF DSGLHPAVKV CQLTDEQIHH LMKMIRDFSI LFYRCRKAGL ALSKHYKVYK RPNCGQCHCR ITVCRFGDNN RMTYFCPHCQ KENPQHVDIC KLPTRNTIIS WTSSRVDHVM DSVARKSEEH WTCVVCTLIN KPSSKACDAC LTSRPIDSVL KSEENSTVFS HLMKYPCNTF GKPHTEVKIN RKTAFGTTTL VLTDFSNKSS TLERKTKQNQ ILDEEFQNSP PASVCLNDIQ HPSKKTTNDI TQPSSKVNIS PTISSESKLF SPAHKKPKTA QYSSPELKSC NPGYSNSELQ INMTDGPRTL NPDSPRCSKH NRLCILRVVG KDGENKGRQF YACPLPREAQ CGFFEWADLS FPFCNHGKRS TMKTVLKIGP NNGKNFFVCP LGKEKQCNFF QWAENGPGIK IIPGC
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