About Nuclear protein localization protein 4 homolog
Nuclear protein localization protein 4 homolog (NPLOC4) is a protein
from Homo sapiens identified by UniProt accession
Q8TAT6, 608 residues long.
MolForge cross-references it against 0 known binders and
91 disease associations.
Target properties
| Protein name | Nuclear protein localization protein 4 homolog |
|---|
| UniProt accession | Q8TAT6 |
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| Gene | NPLOC4 |
|---|
| Organism | Homo sapiens |
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| Length | 608 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (91)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- refractive error measurement · score 0.27
- Myopia · score 0.26
- cataract · score 0.26
- hair color · score 0.24
- mean corpuscular volume · score 0.22
- Astigmatism · score 0.22
- Red cell distribution width · score 0.21
- erythrocyte count · score 0.21
- hair colour measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TAT6-F1 | alphafold | PREDICTED | 87.57 | — |
Amino-acid sequence (608 residues)
MAESIIIRVQ SPDGVKRITA TKRETAATFL KKVAKEFGFQ NNGFSVYINR NKTGEITASS NKSLNLLKIK HGDLLFLFPS SLAGPSSEME TSVPPGFKVF GAPNVVEDEI DQYLSKQDGK IYRSRDPQLC RHGPLGKCVH CVPLEPFDED YLNHLEPPVK HMSFHAYIRK LTGGADKGKF VALENISCKI KSGCEGHLPW PNGICTKCQP SAITLNRQKY RHVDNIMFEN HTVADRFLDF WRKTGNQHFG YLYGRYTEHK DIPLGIRAEV AAIYEPPQIG TQNSLELLED PKAEVVDEIA AKLGLRKVGW IFTDLVSEDT RKGTVRYSRN KDTYFLSSEE CITAGDFQNK HPNMCRLSPD GHFGSKFVTA VATGGPDNQV HFEGYQVSNQ CMALVRDECL LPCKDAPELG YAKESSSEQY VPDVFYKDVD KFGNEITQLA RPLPVEYLII DITTTFPKDP VYTFSISQNP FPIENRDVLG ETQDFHSLAT YLSQNTSSVF LDTISDFHLL LFLVTNEVMP LQDSISLLLE AVRTRNEELA QTWKRSEQWA TIEQLCSTVG GQLPGLHEYG AVGGSTHTAT AAMWACQHCT FMNQPGTGHC EMCSLPRT
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