About DEP domain-containing mTOR-interacting protein
DEP domain-containing mTOR-interacting protein (DEPTOR) is a protein
from Homo sapiens identified by UniProt accession
Q8TB45, 409 residues long.
MolForge cross-references it against 0 known binders and
137 disease associations.
Target properties
| Protein name | DEP domain-containing mTOR-interacting protein |
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| UniProt accession | Q8TB45 |
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| Gene | DEPTOR |
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| Organism | Homo sapiens |
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| Length | 409 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (137)
Diseases linked to this target (Open Targets).
- creatinine measurement · score 0.38
- mean corpuscular hemoglobin · score 0.35
- reticulocyte measurement · score 0.34
- Myocardial Ischemia · score 0.33
- platelet count · score 0.33
- idiopathic pulmonary fibrosis · score 0.29
- mean corpuscular hemoglobin concentration · score 0.28
- heel bone mineral density · score 0.27
- glomerular filtration rate · score 0.26
- platelet crit · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TB45-F1 | alphafold | PREDICTED | 79.73 | — |
Amino-acid sequence (409 residues)
MEEGGSTGSA GSDSSTSGSG GAQQRELERM AEVLVTGEQL RLRLHEEKVI KDRRHHLKTY PNCFVAKELI DWLIEHKEAS DRETAIKLMQ KLADRGIIHH VCDEHKEFKD VKLFYRFRKD DGTFPLDNEV KAFMRGQRLY EKLMSPENTL LQPREEEGVK YERTFMASEF LDWLVQEGEA TTRKEAEQLC HRLMEHGIIQ HVSNKHPFVD SNLLYQFRMN FRRRRRLMEL LNEKSPSSQE THDSPFCLRK QSHDNRKSTS FMSVSPSKEI KIVSAVRRSS MSSCGSSGYF SSSPTLSSSP PVLCNPKSVL KRPVTSEELL TPGAPYARKT FTIVGDAVGW GFVVRGSKPC HIQAVDPSGP AAAAGMKVCQ FVVSVNGLNV LHVDYRTVSN LILTGPRTIV MEVMEELEC
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