Zinc finger protein 519 (ZNF519)

About Zinc finger protein 519

Zinc finger protein 519 (ZNF519) is a protein from Homo sapiens identified by UniProt accession Q8TB69, 540 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Zinc finger protein 519
UniProt accession	Q8TB69
Gene	ZNF519
Organism	Homo sapiens
Length	540 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

protein measurement · score 0.31
macrovascular complications of diabetes · score 0.30
neurodegenerative disease · score 0.25
age at onset · score 0.22
Myopia · score 0.22
plasma fibronectin deficiency · score 0.07
isolated asymptomatic elevation of creatine phosphokinase · score 0.06
cancer · score 0.05
Hereditary persistence of alpha-fetoprotein · score 0.04
congenital lethal erythroderma · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TB69-F1	alphafold	PREDICTED	59.66	—

Amino-acid sequence (540 residues)

MELLTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL VSLAVYSYYN QGILPEQGIQ DSFKKATLGR YGSCGLENIC LWKNWESIGE GEGQKECYNL CSQYLTTSHN KHLTVKGDKE YRIFQKKPQF LSAAPTEPCI PMNKYQHKFL KSVFCNKNQI NFNHDSNISK HHSTHFLENY YNCNECEKVF YQSSKLIFPE NIHIQKKPYN SNECGETSDP FSKLTQHQRI YIGESSQRCN KKCIIVFSQS HLKGHKIINT GEKSVKYKER GKAFTRGLHL GHQKIHTGEK PYKCKKCDKA FNKSSHLAQH QRIHTGEKPF KCKECGKAFN RGSYLTQHQR IHTGERAFKC EECGKAFNRG SYLTQHQRIH TGEKPFRCKE CGKAFNRSSY VTQHQRMHTG EKPFKCKECG KAFNRASHLT QHQRIHTGEK HFKCKECGKA FNRGSHLTRH QRIHTGEKSF KCEECGKAFI WGSHLTQHQR VHTGEKFFKC KECGKAFTRS SHLTQHQRIH TGEKPFKCKE CGKAFNRRST LTQHQIIHTR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards