About NEDD8-activating enzyme E1 catalytic subunit
NEDD8-activating enzyme E1 catalytic subunit (UBA3) is a protein
from Homo sapiens identified by UniProt accession
Q8TBC4, 463 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | NEDD8-activating enzyme E1 catalytic subunit |
|---|
| UniProt accession | Q8TBC4 |
|---|
| Gene | UBA3 |
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| Organism | Homo sapiens |
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| Length | 463 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (68)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.31
- thyroid gland adenocarcinoma · score 0.22
- neurodegenerative disease · score 0.21
- urate measurement · score 0.19
- creatinine measurement · score 0.16
- cystatin C measurement · score 0.15
- sex hormone-binding globulin measurement · score 0.11
- myelodysplastic syndrome · score 0.10
- intrahepatic cholangiocarcinoma · score 0.10
- non-small cell lung carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TBC4-F1 | alphafold | PREDICTED | 92.90 | — |
Amino-acid sequence (463 residues)
MADGEEPEKK RRRIEELLAE KMAVDGGCGD TGDWEGRWNH VKKFLERSGP FTHPDFEPST ESLQFLLDTC KVLVIGAGGL GCELLKNLAL SGFRQIHVID MDTIDVSNLN RQFLFRPKDI GRPKAEVAAE FLNDRVPNCN VVPHFNKIQD FNDTFYRQFH IIVCGLDSII ARRWINGMLI SLLNYEDGVL DPSSIVPLID GGTEGFKGNA RVILPGMTAC IECTLELYPP QVNFPMCTIA SMPRLPEHCI EYVRMLQWPK EQPFGEGVPL DGDDPEHIQW IFQKSLERAS QYNIRGVTYR LTQGVVKRII PAVASTNAVI AAVCATEVFK IATSAYIPLN NYLVFNDVDG LYTYTFEAER KENCPACSQL PQNIQFSPSA KLQEVLDYLT NSASLQMKSP AITATLEGKN RTLYLQSVTS IEERTRPNLS KTLKELGLVD GQELAVADVT TPQTVLFKLH FTS
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