Fibronectin type III domain-containing protein 9…

About Fibronectin type III domain-containing protein 9

Fibronectin type III domain-containing protein 9 (FNDC9) is a protein from Homo sapiens identified by UniProt accession Q8TBE3, 224 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Fibronectin type III domain-containing protein 9
UniProt accession	Q8TBE3
Gene	FNDC9
Organism	Homo sapiens
Length	224 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

body height · score 0.22
serum alanine aminotransferase measurement · score 0.19
age at menarche · score 0.19
appendicular lean mass · score 0.18
serum gamma-glutamyl transferase measurement · score 0.18
sex hormone-binding globulin measurement · score 0.17
sitting height measurement · score 0.16
C-reactive protein measurement · score 0.15
puberty onset measurement · score 0.15
asthma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TBE3-F1	alphafold	PREDICTED	66.80	—

Amino-acid sequence (224 residues)

MNIEVGNISY TGAIISWSSS EPCLEDYYHI MYRPNWNSIF SGYLRYSFHH EEKVPRTISS VVLEHLAPST LYFLCISCKK AAFPYRHYCT MFHTLDKSPL APGSSLVDPQ ISLWVLMAIL LACFTAVLAF ICLQFWCVRC HEPRWSYRAG HMEEANGLVR WPEEAPDLGQ REEDLQGLPL VEMPRKNSRD GAELDPEANQ DAPDAGALQR GGGDPPAILP HCGE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Fibronectin type III domain-containing protein 9 (FNDC9)