Prostamide/prostaglandin F synthase (PRXL2B)

About Prostamide/prostaglandin F synthase

Prostamide/prostaglandin F synthase (PRXL2B) is a protein from Homo sapiens identified by UniProt accession Q8TBF2, 198 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.

Target properties

Protein name	Prostamide/prostaglandin F synthase
UniProt accession	Q8TBF2
Gene	PRXL2B
Organism	Homo sapiens
Length	198 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (79)

Diseases linked to this target (Open Targets).

multiple sclerosis · score 0.19
Eczematoid dermatitis · score 0.18
hypothyroidism · score 0.17
allergic rhinitis · score 0.17
asthma · score 0.15
sclerosing cholangitis · score 0.14
myxedema · score 0.13
rheumatoid arthritis · score 0.13
Thyroid preparation use measurement · score 0.13
Hashimoto's thyroiditis · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TBF2-F1	alphafold	PREDICTED	92.38	—

Amino-acid sequence (198 residues)

MSTVDLARVG ACILKHAVTG EAVELRSLWR EHACVVAGLR RFGCVVCRWI AQDLSSLAGL LDQHGVRLVG VGPEALGLQE FLDGDYFAGE LYLDESKQLY KELGFKRYNS LSILPAALGK PVRDVAAKAK AVGIQGNLSG DLLQSGGLLV VSKGGDKVLL HFVQKSPGDY VPKEHILQVL GISAEVCASD PPQCDREV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards