About Guanine nucleotide exchange factor for Rab-3A
Guanine nucleotide exchange factor for Rab-3A (RAB3IL1) is a protein
from Homo sapiens identified by UniProt accession
Q8TBN0, 382 residues long.
MolForge cross-references it against 0 known binders and
78 disease associations.
Target properties
| Protein name | Guanine nucleotide exchange factor for Rab-3A |
|---|
| UniProt accession | Q8TBN0 |
|---|
| Gene | RAB3IL1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 382 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (78)
Diseases linked to this target (Open Targets).
- sphingolipid measurement · score 0.30
- aspartate aminotransferase measurement · score 0.29
- mean corpuscular hemoglobin · score 0.28
- mean corpuscular hemoglobin concentration · score 0.27
- forced expiratory volume · score 0.24
- phosphatidylcholine 38:4 measurement · score 0.24
- schizophrenia · score 0.23
- alpha-linolenic acid measurement · score 0.21
- vital capacity · score 0.20
- lysophosphatidylcholine measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TBN0-F1 | alphafold | PREDICTED | 78.42 | — |
Amino-acid sequence (382 residues)
MWSGPPQPDQ GLPPPLAAVP VPWKSTDPCQ GHRESPGALV ETSAGEEAQG QEGPAAAQLD VLRLRSSSME IREKGSEFLK EELHRAQKEL KLKDEECERL SKVREQLEQE LEELTASLFE EAHKMVREAN MKQAASEKQL KEARGKIDML QAEVTALKTL VITSTPASPN RELHPQLLSP TKAGPRKGHS RHKSTSSTLC PAVCPAAGHT LTPDREGKEV DTILFAEFQA WRESPTLDKT CPFLERVYRE DVGPCLDFTM QELSVLVRAA VEDNTLTIEP VASQTLPTVK VAEVDCSSTN TCALSGLTRT CRHRIRLGDS KSHYYISPSS RARITAVCNF FTYIRYIQQG LVRQDAEPMF WEIMRLRKEM SLAKLGFFPQ EA
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