About Polyamine-modulated factor 1-binding protein 1
Polyamine-modulated factor 1-binding protein 1 (PMFBP1) is a protein
from Homo sapiens identified by UniProt accession
Q8TBY8, 1007 residues long.
MolForge cross-references it against 0 known binders and
158 disease associations.
Target properties
| Protein name | Polyamine-modulated factor 1-binding protein 1 |
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| UniProt accession | Q8TBY8 |
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| Gene | PMFBP1 |
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| Organism | Homo sapiens |
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| Length | 1007 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (158)
Diseases linked to this target (Open Targets).
- spermatogenic failure 31 · score 0.62
- alkaline phosphatase measurement · score 0.43
- chronotype measurement · score 0.42
- blood protein measurement · score 0.41
- azoospermia · score 0.40
- low density lipoprotein cholesterol measurement · score 0.38
- total cholesterol measurement · score 0.38
- haptoglobin measurement · score 0.37
- unipolar depression · score 0.37
- serum alanine aminotransferase measurement · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TBY8-F1 | alphafold | PREDICTED | 77.39 | — |
Amino-acid sequence (1007 residues)
MKDEAGERDR EVSSLNSKLL SLQLDIKNLH DVCKRQRKTL QDNQLCMEEA MNSSHDKKQA QALAFEESEV EFGSSKQCHL RQLQQLKKKL LVLQQELEFH TEELQTSYYS LRQYQSILEK QTSDLVLLHH HCKLKEDEVI LYEEEMGNHN ENTGEKLHLA QEQLALAGDK IASLERSLNL YRDKYQSSLS NIELLECQVK MLQGELGGIM GQEPENKGDH SKVRIYTSPC MIQEHQETQK RLSEVWQKVS QQDDLIQELR NKLACSNALV LEREKALIKL QADFASCTAT HRYPPSSSEE CEDIKKILKH LQEQKDSQCL HVEEYQNLVK DLRVELEAVS EQKRNIMKDM MKLELDLHGL REETSAHIER KDKDITILQC RLQELQLEFT ETQKLTLKKD KFLQEKDEML QELEKKLTQV QNSLLKKEKE LEKQQCMATE LEMTVKEAKQ DKSKEAECKA LQAEVQKLKN SLEEAKQQER LAAQQAAQCK EEAALAGCHL EDTQRKLQKG LLLDKQKADT IQELQRELQM LQKESSMAEK EQTSNRKRVE ELSLELSEAL RKLENSDKEK RQLQKTVAEQ DMKMNDMLDR IKHQHREQGS IKCKLEEDLQ EATKLLEDKR EQLKKSKEHE KLMEGELEAL RQEFKKKDKT LKENSRKLEE ENENLRAELQ CCSTQLESSL NKYNTSQQVI QDLNKEIALQ KESLMSLQAQ LDKALQKEKH YLQTTITKEA YDALSRKSAA CQDDLTQALE KLNHVTSETK SLQQSLTQTQ EKKAQLEEEI IAYEERMKKL NTELRKLRGF HQESELEVHA FDKKLEEMSC QVLQWQKQHQ NDLKMLAAKE EQLREFQEEM AALKENLLED DKEPCCLPQW SVPKDTCRLY RGNDQIMTNL EQWAKQQKVA NEKLGNQLRE QVKYIAKLSG EKDHLHSVMV HLQQENKKLK KEIEEKKMKA ENTRLCTKAL GPSRTESTQR EKVCGTLGWK GLPQDMGQRM DLTKYIGMPH CPGSSYC
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