Cilia- and flagella-associated protein 251 (CFAP251)

About Cilia- and flagella-associated protein 251

Cilia- and flagella-associated protein 251 (CFAP251) is a protein from Homo sapiens identified by UniProt accession Q8TBY9, 1149 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.

Target properties

Protein name	Cilia- and flagella-associated protein 251
UniProt accession	Q8TBY9
Gene	CFAP251
Organism	Homo sapiens
Length	1149 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (66)

Diseases linked to this target (Open Targets).

azoospermia · score 0.61
non-syndromic male infertility due to sperm motility disorder · score 0.51
mean platelet volume · score 0.43
male infertility with teratozoospermia due to single gene mutation · score 0.42
platelet count · score 0.36
Reduced sperm motility · score 0.33
spermatogenic failure 18 · score 0.33
liver fibrosis measurement · score 0.31
systolic blood pressure · score 0.31
lean body mass · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TBY9-F1	alphafold	PREDICTED	76.62	—

Amino-acid sequence (1149 residues)

MSDAAEAPRE ATGENGETEM KEEEEPNPNY KEVEDPQQES KDDTIAWRES QEEERKTGEE EGEEEGKEDK KIVMEETEEK AGEVQEKEAS GIQEETTVEP QEVTASMIRL ETQITDSQSI TSGIFPKTQR GSKSKLSLQL EDAETDELLR DLSTQIEFLD LDQISPEEQQ ISSPERQPSG ELEEKTDRMP QDELGQERRD LEPENREEGQ ERRVSDIQSK AGISRESLVS STTEDILFQK DKSTPVYPLT MTWSFGWNSS LPVYYIREER QRVLLYVCAH TAIIYNVFRN NQYHLQGHAN IISCLCVSED RRWIATADKG PDCLVIIWDS FTGIPVHTIF DSCPEGNGIM AMAMTHDAKY LATISDAEVQ KVCIWKWTLA VETPACTLEL PTEYGVQNYV TFNPTNNKEL VSNSKTRAIY YAWYEERDTL AHSAPLLTEK TFNKLVGKFS QSIFHLNLTQ ILSATMEGKL VVWDIHRPPS SASTFLGFPY IKPCKLVHLQ KEGITVLTTI DSYIVTGDIK GNIKFYDHTL SIVNWYSHLK LGAIRTLSFS KTPATPPTEK SNYPPDCTLK GDLFVLRNFI IGTSDAAVYH LTTDGTKLEK LFVEPKDAIC AISCHPYQPL IAIGSICGMI KVWNYENKQY LFSRVFEKGL GVQSLTYNPE GALLGAGFTE GTVYILDAMS LENESPEPFK YSRTSVTHIS FSHDSQYMAT ADRSFTVAVY MLVVRNGQRV WEYLARLRSH RKSIRSLLFG VYLDSNEPRL LSLGTDRLLI EYDLLRSYKD HLEVLDIHHT DQGCYPTCMV WYPPLTRELF LLICNSGYKV KLFNATTKMC RKTLLGPAYG SPIEQTQVLP VRSMAELQKR YLVFINRDKV GLQILPVDGN PHKTSAIVCH PNGVAGMAVS YDGCYAFTAG GHDRSVVQWK ITLSVLEAAV SLGGEDLTPF YGLLSGGREG KFYRELEDYF YYSQLRSQGI DTMETRKVSE HICLSELPFV MRAIGFYPSE EKIDDIFNEI KFGEYVDTGK LIDKINLPDF LKVYLNHKPP FGNTMSGIHK SFEVLGYTNS KGKKAIRRED FLRLLVTKGE HMTEEEMLDC FASLFGLNPE GWKSEPATCS VKGSEICLEE ELPDEITAEI FATEILGLTI SEDSGQDGQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards