About TBC1 domain family member 15
TBC1 domain family member 15 (TBC1D15) is a protein
from Homo sapiens identified by UniProt accession
Q8TC07, 691 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | TBC1 domain family member 15 |
|---|
| UniProt accession | Q8TC07 |
|---|
| Gene | TBC1D15 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 691 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (34)
Diseases linked to this target (Open Targets).
- myocardial infarction · score 0.07
- neoplasm · score 0.06
- myeloid white cell count · score 0.04
- Dilated cardiomyopathy · score 0.03
- small intestine cancer · score 0.03
- hepatocellular carcinoma · score 0.03
- aspartate aminotransferase measurement · score 0.02
- body mass index · score 0.02
- low density lipoprotein cholesterol measurement · score 0.02
- cholangiocarcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TC07-F1 | alphafold | PREDICTED | 70.68 | — |
Amino-acid sequence (691 residues)
MAAAGVVSGK IIYEQEGVYI HSSCGKTNDQ DGLISGILRV LEKDAEVIVD WRPLDDALDS SSILYARKDS SSVVEWTQAP KERGHRGSEH LNSYEAEWDM VNTVSFKRKP HTNGDAPSHR NGKSKWSFLF SLTDLKSIKQ NKEGMGWSYL VFCLKDDVVL PALHFHQGDS KLLIESLEKY VVLCESPQDK RTLLVNCQNK SLSQSFENLL DEPAYGLIQA GLLDRRKLLW AIHHWKKIKK DPYTATMIGF SKVTNYIFDS LRGSDPSTHQ RPPSEMADFL SDAIPGLKIN QQEEPGFEVI TRIDLGERPV VQRREPVSLE EWTKNIDSEG RILNVDNMKQ MIFRGGLSHA LRKQAWKFLL GYFPWDSTKE ERTQLQKQKT DEYFRMKLQW KSISQEQEKR NSRLRDYRSL IEKDVNRTDR TNKFYEGQDN PGLILLHDIL MTYCMYDFDL GYVQGMSDLL SPLLYVMENE VDAFWCFASY MDQMHQNFEE QMQGMKTQLI QLSTLLRLLD SGFCSYLESQ DSGYLYFCFR WLLIRFKREF SFLDILRLWE VMWTELPCTN FHLLLCCAIL ESEKQQIMEK HYGFNEILKH INELSMKIDV EDILCKAEAI SLQMVKCKEL PQAVCEILGL QGSEVTTPDS DVGEDENVVM TPCPTSAFQS NALPTLSASG ARNDSPTQIP VSSDVCRLTP A
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