About Retinol dehydrogenase 11
Retinol dehydrogenase 11 (RDH11) is a protein
from Homo sapiens identified by UniProt accession
Q8TC12, 318 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Retinol dehydrogenase 11 |
|---|
| UniProt accession | Q8TC12 |
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| Gene | RDH11 |
|---|
| Organism | Homo sapiens |
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| Length | 318 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (38)
Diseases linked to this target (Open Targets).
- Genetic malformation syndrome with short stature · score 0.60
- neurodegenerative disease · score 0.36
- lung adenocarcinoma · score 0.22
- cutaneous melanoma · score 0.18
- head and neck squamous cell carcinoma · score 0.15
- breast adenocarcinoma · score 0.15
- endometrial cancer · score 0.09
- PHF-tau measurement · score 0.09
- creatinine measurement · score 0.06
- glomerular filtration rate · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TC12-F1 | alphafold | PREDICTED | 91.93 | — |
Amino-acid sequence (318 residues)
MVELMFPLLL LLLPFLLYMA APQIRKMLSS GVCTSTVQLP GKVVVVTGAN TGIGKETAKE LAQRGARVYL ACRDVEKGEL VAKEIQTTTG NQQVLVRKLD LSDTKSIRAF AKGFLAEEKH LHVLINNAGV MMCPYSKTAD GFEMHIGVNH LGHFLLTHLL LEKLKESAPS RIVNVSSLAH HLGRIHFHNL QGEKFYNAGL AYCHSKLANI LFTQELARRL KGSGVTTYSV HPGTVQSELV RHSSFMRWMW WLFSFFIKTP QQGAQTSLHC ALTEGLEILS GNHFSDCHVA WVSAQARNET IARRLWDVSC DLLGLPID
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