GRB2-related adapter protein-like (GRAPL)

About GRB2-related adapter protein-like

GRB2-related adapter protein-like (GRAPL) is a protein from Homo sapiens identified by UniProt accession Q8TC17, 118 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.

Target properties

Protein name	GRB2-related adapter protein-like
UniProt accession	Q8TC17
Gene	GRAPL
Organism	Homo sapiens
Length	118 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TC17-F1	alphafold	PREDICTED	86.16	—

Amino-acid sequence (118 residues)

MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK NYIRVKPHPW YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN NRAQRGPCLG PKSHSRLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards