About Cancer-associated gene 1 protein
Cancer-associated gene 1 protein (CAGE1) is a protein
from Homo sapiens identified by UniProt accession
Q8TC20, 777 residues long.
MolForge cross-references it against 0 known binders and
97 disease associations.
Target properties
| Protein name | Cancer-associated gene 1 protein |
|---|
| UniProt accession | Q8TC20 |
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| Gene | CAGE1 |
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| Organism | Homo sapiens |
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| Length | 777 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (97)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.13
- Immature Reticulocyte Fraction Measurement · score 0.09
- neoplasm · score 0.08
- serum alanine aminotransferase measurement · score 0.06
- heel bone mineral density · score 0.05
- sex hormone-binding globulin measurement · score 0.05
- leukocyte count · score 0.05
- triglyceride measurement · score 0.04
- reticulocyte measurement · score 0.04
- diabetes mellitus · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TC20-F1 | alphafold | PREDICTED | 62.42 | — |
Amino-acid sequence (777 residues)
MNKDYQKFWS SPSDPVHFEV DTSHEKVESM SESDTMNVSN LSQGVMLSHS PICMETTGTT CDLPQNEIKN FERENEYEST LCEDAYGTLD NLLNDNNIEN YSTNALIQPV DTISISSLRQ FETVCKFHWV EAFDDEMTEK PEFQSQVYNY AKDNNIKQDS FKEENPMETS VSANTDQLGN EYFRQPPPRS PPLIHCSGEM LKFTEKSLAK SIAKESALNP SQPPSFLCKT AVPSKEIQNY GEIPEMSVSY EKEVTAEGVE RPEIVSTWSS AGISWRSEAC RENCEMPDWE QSAESLQPVQ EDMALNEVLQ KLKHTNRKQE VRIQELQCSN LYLEKRVKEL QMKITKQQVF IDVINKLKEN VEELIEDKYK IILEKNDTKK TLQNLEEVLA NTQKHLQESR NDKEMLQLQF KKIKANYVCL QERYMTEMQQ KNKSVSQYLE MDKTLSKKEE EVERLQQLKK ELEKATASAL DLLKREKEAQ EQEFLSLQEE FQKLEKENLE ERQKLKSRLE KLLTQVRNLQ FMSENERTKN IKLQQQINEV KNENAKLKQQ VARSEEQNYV PKFETAQLKD QLEEVLKSDI TKDTKTTHSN LLPDCSPCEE RLNPADIKRA SQLASKMHSL LALMVGLLTC QDIINSDAEH FKESEKVSDI MLQKLKSLHL KKKTLDKEVI DCDSDEAKSI RDVPTLLGAK LDKYHSLNEE LDFLVTSYEE IIECADQRLA ISHSQIAHLE ERNKHLEDLI RKPREKARKP RSKSLENHPK SMTMMPALFK ENRNDLD
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