About Golgi-associated RAB2 interactor protein 3
Golgi-associated RAB2 interactor protein 3 (GARIN3) is a protein
from Homo sapiens identified by UniProt accession
Q8TC56, 605 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | Golgi-associated RAB2 interactor protein 3 |
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| UniProt accession | Q8TC56 |
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| Gene | GARIN3 |
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| Organism | Homo sapiens |
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| Length | 605 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (13)
Diseases linked to this target (Open Targets).
- Thyroid preparation use measurement · score 0.18
- thyroid disease · score 0.14
- heel bone mineral density · score 0.07
- respiratory system disease · score 0.06
- T-cell immunoglobulin and mucin domain 1 measurement · score 0.05
- hyperthyroidism · score 0.04
- leukocyte count · score 0.04
- eosinophil count · score 0.03
- carcinoma of liver and intrahepatic biliary tract · score 0.03
- breast carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TC56-F1 | alphafold | PREDICTED | 50.28 | — |
Amino-acid sequence (605 residues)
MSNESCLPYY TAHSYSSMSA FKTSMGDLQR QLYNRGEYNI FKYAPMFESN FIQINKKGEV IDVHNRVRMV TVGIVCTSPI LPLPDVMVLA QPTKICEQHV RWGRFAKGRG RRPVKTLELT RLLPLKFVKI SIHDHEKQQL RLKLATGRTF YLQLCPSSDT REDLFCYWEK LVYLLRPPVE SYCSTPTLLS GDAPPEDNKS LVAAELHREG DQSETGLYKP CDVSAATSSA YAGGEGIQHA SHGTASAASP STSTPGAAEG GAARTAGGMA VAGTATGPRT DVAIAGAAMS PATGAMSIAT TKSAGPGQVT TALAGAAIKN PGENESSKSM AGAANISSEG ISLALVGAAS TSLEGTSTSM AGAASLSQDS SLSAAFAGSI TTSKCAAERT EGPAVGPLIS TLQSEGYMSE RDGSQKVSQP SAEVWNENKE RREKKDRHPS RKSSHHRKAG ESHRRRAGDK NQKASSHRSA SGHKNTRDDK KEKGYSNVRG KRHGSSRKSS THSSTKKESR TTQELGKNQS ASSTGALQKK ASKISSFLRS LRATPGSKTR VTSHDREVDI VAKMVEKQNI EAKVEKAQGG QELEMISGTM TSEKTEMIVF ETKSI
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