About Meiosis 1 arrest protein
Meiosis 1 arrest protein (M1AP) is a protein
from Homo sapiens identified by UniProt accession
Q8TC57, 530 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | Meiosis 1 arrest protein |
|---|
| UniProt accession | Q8TC57 |
|---|
| Gene | M1AP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 530 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (120)
Diseases linked to this target (Open Targets).
- spermatogenic failure 48 · score 0.59
- azoospermia · score 0.42
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.35
- body height · score 0.16
- adolescent idiopathic scoliosis · score 0.14
- type 1 diabetes mellitus · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.07
- spinocerebellar ataxia type 32 · score 0.06
- congenital bilateral absence of vas deferens · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TC57-F1 | alphafold | PREDICTED | 73.38 | — |
Amino-acid sequence (530 residues)
MHPGRTTGKG PSTHTQIDQQ PPRLLIVHIA LPSWADICTN LCEALQNFFS LACSLMGPSR MSLFSLYMVQ DQHECILPFV QVKGNFARLQ TCISELRMLQ REGCFRSQGA SLRLAVEDGL QQFKQYSRHV TTRAALTYTS LEITILTSQP GKEVVKQLEE GLKDTDLARV RRFQVVEVTK GILEHVDSAS PVEDTSNDES SILGTDIDLQ TIDNDIVSME IFFKAWLHNS GTDQEQIHLL LSSQCFSNIS RPRDNPMCLK CDLQERLLCP SLLAGTADGS LRMDDPKGDF ITLYQMASQS SASHYKLQVI KALKSSGLCE SLTYGLPFIL RPTSCWQLDW DELETNQQHF HALCHSLLKR EWLLLAKGEP PGPGHSQRIP ASTFYVIMPS HSLTLLVKAV ATRELMLPST FPLLPEDPHD DSLKNVESML DSLELEPTYN PLHVQSHLYS HLSSIYAKPQ GRLHPHWESR APRKHPCKTG QLQTNRARAT VAPLPMTPVP GRASKMPAAS KSSSDAFFLP SEWEKDPSRP
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