Mitochondria-eating protein (SPATA18)

About Mitochondria-eating protein

Mitochondria-eating protein (SPATA18) is a protein from Homo sapiens identified by UniProt accession Q8TC71, 538 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.

Target properties

Protein name	Mitochondria-eating protein
UniProt accession	Q8TC71
Gene	SPATA18
Organism	Homo sapiens
Length	538 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (87)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.48
platelet count · score 0.38
body height · score 0.35
fat body mass · score 0.32
serum alanine aminotransferase measurement · score 0.29
lean body mass · score 0.25
body weight · score 0.25
protein measurement · score 0.25
body mass index · score 0.23
whole body water mass · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TC71-F1	alphafold	PREDICTED	75.37	—

Amino-acid sequence (538 residues)

MAENLKRLVS NETLRTLQEK LDFWLKEYNT NTCDQNLNHC LELIEQVAKV QGQLFGILTA AAQEGGRNDG VETIKSRLLP WLEASFTAAS LGKSVDSKVP SLQDTFDRER HKDPSPRDRD MQQLDSNLNS TRSQCNQVQD DLVETEKNLE ESKNRSAISL LAAEEEINQL KKQLKSLQAQ EDARHRNTDQ RSSENRRSEP WSLEERKREQ WNSLKQNADQ QDTEAMSDYK KQLRNLKEEI AVLSAEKSAL QGRSSRSRSP SPAPRSRSCS RSRSASPSTA VKVRRPSPNR SKLSNVARKA ALLSRFSDSY SQARLDAQCL LRRCIDKAET VQRIIYIATV EAFHVAKMAF RHFKIHVRKS LTPSYVGSND FENAVLDYVI CHLDLYDSQS SVNDVIRAMN VNPKISFPPV VDFCLLSDFI QEICCIAFAM QALEPPLDIA YGADGEVFND CKYRRSYDSD FTAPLVLYHV WPALMENDCV IMKGEAVTRR GAFWNSVRSV SRCRSRSLSP ICPRSQIGLN TMSRSRSPSP IRCGLPRF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards