About Ecto-NOX disulfide-thiol exchanger 1
Ecto-NOX disulfide-thiol exchanger 1 (ENOX1) is a protein
from Homo sapiens identified by UniProt accession
Q8TC92, 643 residues long.
MolForge cross-references it against 0 known binders and
112 disease associations.
Target properties
| Protein name | Ecto-NOX disulfide-thiol exchanger 1 |
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| UniProt accession | Q8TC92 |
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| Gene | ENOX1 |
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| Organism | Homo sapiens |
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| Length | 643 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (112)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.45
- unipolar depression · score 0.44
- schizophrenia · score 0.41
- bipolar disorder · score 0.40
- obsessive-compulsive disorder · score 0.32
- attention deficit hyperactivity disorder · score 0.32
- Tourette syndrome · score 0.32
- autism spectrum disorder · score 0.32
- anorexia nervosa · score 0.32
- autosomal dominant compelling helio-ophthalmic outburst syndrome · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TC92-F1 | alphafold | PREDICTED | 74.12 | — |
Amino-acid sequence (643 residues)
MVDAGGVENI TQLPQELPQM MAAAADGLGS IAIDTTQLNM SVTDPTAWAT AMNNLGMVPV GLPGQQLVSD SICVPGFDPS LNMMTGITPI NPMIPGLGLV PPPPPTEVAV VKEIIHCKSC TLFPQNPNLP PPSTRERPPG CKTVFVGGLP ENATEEIIQE VFEQCGDITA IRKSKKNFCH IRFAEEFMVD KAIYLSGYRM RLGSSTDKKD SGRLHVDFAQ ARDDFYEWEC KQRMRAREER HRRKLEEDRL RPPSPPAIMH YSEHEAALLA EKLKDDSKFS EAITVLLSWI ERGEVNRRSA NQFYSMVQSA NSHVRRLMNE KATHEQEMEE AKENFKNALT GILTQFEQIV AVFNASTRQK AWDHFSKAQR KNIDIWRKHS EELRNAQSEQ LMGIRREEEM EMSDDENCDS PTKKMRVDES ALAAQAYALK EENDSLRWQL DAYRNEVELL KQEKEQLFRT EENLTKDQQL QFLQQTMQGM QQQLLTIQEE LNNKKSELEQ AKEEQSHTQA LLKVLQEQLK GTKELVETNG HSHEDSNEIN VLTVALVNQD RENNIEKRSQ GLKSEKEALL IGIISTFLHV HPFGANIEYL WSYMQQLDSK ISANEIEMLL MRLPRMFKQE FTGVGATLEK RWKLCAFEGI KTT
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