Actin-like protein 9 (ACTL9)

About Actin-like protein 9

Actin-like protein 9 (ACTL9) is a protein from Homo sapiens identified by UniProt accession Q8TC94, 416 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.

Target properties

Protein name	Actin-like protein 9
UniProt accession	Q8TC94
Gene	ACTL9
Organism	Homo sapiens
Length	416 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (88)

Diseases linked to this target (Open Targets).

spermatogenic failure 53 · score 0.58
non-syndromic male infertility due to sperm motility disorder · score 0.37
late-onset Alzheimers disease · score 0.14
azoospermia · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.09
birth weight · score 0.07
atopic eczema · score 0.07
partial chromosome Y deletion · score 0.07
spermatogenic failure 20 · score 0.07
mosquito bite reaction itch intensity measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TC94-F1	alphafold	PREDICTED	87.21	—

Amino-acid sequence (416 residues)

MDASRPKSSE SQSSLEAPRP GPNPSPNVVN KPLQRDSPGM VADRLPPKTG AVVIDMGTGT CKVGFAGQAS PTYTVATILG CQPKKPATSG QSGLQTFIGE AARVLPELTL VQPLRSGIVV DWDAAELIWR HLLEHDLRVA THDHPLLFSD PPFSPATNRE KLVEVAFESL RSPAMYVASQ SVLSVYAHGR VSGLVVDTGH GVTYTVPVFQ GYNLLHATER LDLAGNNLTA FLAEMLLQAG LPLGQQDLDL VENIKHHYCY VASDFQKEQA RPEQEYKRTL KLPDGRTVTL GKELFQCPEL LFNPPEVPGL SPVGLSTMAK QSLRKLSLEM RADLAQNVLL CGGSSLFTGF EGRFRAELLR ALPAETHVVV AAQPTRNFSV WIGGSILASL RAFQSCWVLR EQYEEQGPYI VYRKCY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards