tRNA N(3)-cytidine methyltransferase METTL6 (METTL6)

About tRNA N(3)-cytidine methyltransferase METTL6

tRNA N(3)-cytidine methyltransferase METTL6 (METTL6) is a protein from Homo sapiens identified by UniProt accession Q8TCB7, 284 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	tRNA N(3)-cytidine methyltransferase METTL6
UniProt accession	Q8TCB7
Gene	METTL6
Organism	Homo sapiens
Length	284 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TCB7-F1	alphafold	PREDICTED	91.87	—

Amino-acid sequence (284 residues)

MASLQRKGLQ ARILTSEEEE KLKRDQTLVS DFKQQKLEQE AQKNWDLFYK RNSTNFFKDR HWTTREFEEL RSCREFEDQK LTMLEAGCGV GNCLFPLLEE DPNIFAYACD FSPRAIEYVK QNPLYDTERC KVFQCDLTKD DLLDHVPPES VDVVMLIFVL SAVHPDKMHL VLQNIYKVLK PGKSVLFRDY GLYDHAMLRF KASSKLGENF YVRQDGTRSY FFTDDFLAQL FMDTGYEEVV NEYVFRETVN KKEGLCVPRV FLQSKFLKPP KNPSPVVLGL DPKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards