About 5'(3')-deoxyribonucleotidase, cytosolic type
5'(3')-deoxyribonucleotidase, cytosolic type (NT5C) is a protein
from Homo sapiens identified by UniProt accession
Q8TCD5, 201 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | 5'(3')-deoxyribonucleotidase, cytosolic type |
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| UniProt accession | Q8TCD5 |
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| Gene | NT5C |
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| Organism | Homo sapiens |
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| Length | 201 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (64)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.19
- sex hormone-binding globulin measurement · score 0.18
- C-reactive protein measurement · score 0.17
- creatinine measurement · score 0.11
- neoplasm · score 0.10
- HbA1c measurement · score 0.08
- Pallister-Hall syndrome · score 0.07
- aspartate aminotransferase measurement · score 0.03
- papilloma · score 0.03
- triple-negative breast cancer · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TCD5-F1 | alphafold | PREDICTED | 96.09 | — |
Amino-acid sequence (201 residues)
MARSVRVLVD MDGVLADFEA GLLRGFRRRF PEEPHVPLEQ RRGFLAREQY RALRPDLADK VASVYEAPGF FLDLEPIPGA LDAVREMNDL PDTQVFICTS PLLKYHHCVG EKYRWVEQHL GPQFVERIIL TRDKTVVLGD LLIDDKDTVR GQEETPSWEH ILFTCCHNRH LVLPPTRRRL LSWSDNWREI LDSKRGAAQR E
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