DENN domain-containing protein 10 (DENND10)

About DENN domain-containing protein 10

DENN domain-containing protein 10 (DENND10) is a protein from Homo sapiens identified by UniProt accession Q8TCE6, 357 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	DENN domain-containing protein 10
UniProt accession	Q8TCE6
Gene	DENND10
Organism	Homo sapiens
Length	357 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.36
myeloid white cell count · score 0.25
platelet crit · score 0.18
keratoconus · score 0.14
carpal tunnel syndrome · score 0.09
leukocyte count · score 0.06
acromesomelic dysplasia 2B · score 0.04
Gollop-Wolfgang complex · score 0.04
syndactyly type 4 · score 0.04
ghosal hematodiaphyseal dysplasia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TCE6-F1	alphafold	PREDICTED	90.68	—

Amino-acid sequence (357 residues)

MAAAEVADTQ LMLGVGLIEK DTNGEVLWVW CYPSTTATLR NLLLRKCCLT DENKLLHPFV FGQYRRTWFY ITTIEVPDSS ILKKVTHFSI VLTAKDFNPE KYAAFTRILC RMYLKHGSPV KMMESYIAVL TKGICQSEEN GSFLSKDFDA RKAYLAGSIK DIVSQFGMET VILHTALMLK KRIVVYHPKI EAVQEFTRTL PALVWHRQDW TILHSYVHLN ADELEALQMC TGYVAGFVDL EVSNRPDLYD VFVNLAESEI TIAPLAKEAM AMGKLHKEMG QLIVQSAEDP EKSESHVIQD IALKTREIFT NLAPFSEVSA DGEKRVLNLE ALKQKRFPPA TENFLYHLAA AEQMLKI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards