About Phosphatidylinositol 4-kinase type 2-beta
Phosphatidylinositol 4-kinase type 2-beta (PI4K2B) is a protein
from Homo sapiens identified by UniProt accession
Q8TCG2, 481 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Phosphatidylinositol 4-kinase type 2-beta |
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| UniProt accession | Q8TCG2 |
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| Gene | PI4K2B |
|---|
| Organism | Homo sapiens |
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| Length | 481 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (28)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.25
- protein measurement · score 0.24
- head and neck squamous cell carcinoma · score 0.19
- lung adenocarcinoma · score 0.19
- cutaneous melanoma · score 0.18
- squamous cell lung carcinoma · score 0.12
- autism · score 0.12
- blood protein measurement · score 0.08
- gut microbiome measurement · score 0.07
- small cell lung carcinoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TCG2-F1 | alphafold | PREDICTED | 75.75 | — |
Amino-acid sequence (481 residues)
MEDPSEPDRL ASADGGSPEE EEDGEREPLL PRIAWAHPRR GAPGSAVRLL DAAGEEGEAG DEELPLPPGD VGVSRSSSAE LDRSRPAVSV TIGTSEMNAF LDDPEFADIM LRAEQAIEVG IFPERISQGS SGSYFVKDPK RKIIGVFKPK SEEPYGQLNP KWTKYVHKVC CPCCFGRGCL IPNQGYLSEA GAYLVDNKLH LSIVPKTKVV WLVSETFNYN AIDRAKSRGK KYALEKVPKV GRKFHRIGLP PKIGSFQLFV EGYKEAEYWL RKFEADPLPE NIRKQFQSQF ERLVILDYII RNTDRGNDNW LVRYEKQKCE KEIDHKESKW IDDEEFLIKI AAIDNGLAFP FKHPDEWRAY PFHWAWLPQA KVPFSEEIRN LILPYISDMN FVQDLCEDLY ELFKTDKGFD KATFESQMSV MRGQILNLTQ ALRDGKSPFQ LVQIPCVIVE RSQGGSQGRI VHLSNSFTQT VNCRKPFFSS W
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