F-box only protein 25 (FBXO25)

About F-box only protein 25

F-box only protein 25 (FBXO25) is a protein from Homo sapiens identified by UniProt accession Q8TCJ0, 367 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	F-box only protein 25
UniProt accession	Q8TCJ0
Gene	FBXO25
Organism	Homo sapiens
Length	367 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

protein measurement · score 0.37
lymphocyte count · score 0.28
fetal genotype effect measurement · score 0.24
interleukin 4 measurement · score 0.24
attention deficit hyperactivity disorder · score 0.04
Mantle cell lymphoma · score 0.03
ichthyosis-hepatosplenomegaly-cerebellar degeneration syndrome · score 0.03
hemoglobin D disease · score 0.03
dominant beta-thalassemia · score 0.03
Hurler-Scheie syndrome · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TCJ0-F1	alphafold	PREDICTED	75.99	—

Amino-acid sequence (367 residues)

MPFLGQDWRS PGWSWIKTED GWKRCESCSQ KLERENNRCN ISHSIILNSE DGEIFNNEEH EYASKKRKKD HFRNDTNTQS FYREKWIYVH KESTKERHGY CTLGEAFNRL DFSSAIQDIR RFNYVVKLLQ LIAKSQLTSL SGVAQKNYFN ILDKIVQKVL DDHHNPRLIK DLLQDLSSTL CILIRGVGKS VLVGNINIWI CRLETILAWQ QQLQDLQMTK QVNNGLTLSD LPLHMLNNIL YRFSDGWDII TLGQVTPTLY MLSEDRQLWK KLCQYHFAEK QFCRHLILSE KGHIEWKLMY FALQKHYPAK EQYGDTLHFC RHCSILFWKD YHLALLFKDS GHPCTAADPD SCFTPVSPQH FIDLFKF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards