About E3 ubiquitin-protein ligase MARCHF1
E3 ubiquitin-protein ligase MARCHF1 (MARCHF1) is a protein
from Homo sapiens identified by UniProt accession
Q8TCQ1, 289 residues long.
MolForge cross-references it against 0 known binders and
128 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase MARCHF1 |
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| UniProt accession | Q8TCQ1 |
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| Gene | MARCHF1 |
|---|
| Organism | Homo sapiens |
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| Length | 289 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (128)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.34
- bone density · score 0.28
- heart rate · score 0.27
- response to beta blocker · score 0.27
- adolescent idiopathic scoliosis · score 0.25
- heel bone mineral density · score 0.22
- multiple sclerosis · score 0.14
- hepatocellular carcinoma · score 0.10
- neoplasm · score 0.09
- insulin resistance · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TCQ1-F1 | alphafold | PREDICTED | 68.41 | — |
Amino-acid sequence (289 residues)
MLGWCEAIAR NPHRIPNNTR TPEISGDLAD ASQTSTLNEK SPGRSASRSS NISKASSPTT GTAPRSQSRL SVCPSTQDIC RICHCEGDEE SPLITPCRCT GTLRFVHQSC LHQWIKSSDT RCCELCKYDF IMETKLKPLR KWEKLQMTTS ERRKIFCSVT FHVIAITCVV WSLYVLIDRT AEEIKQGNDN GVLEWPFWTK LVVVAIGFTG GLVFMYVQCK VYVQLWRRLK AYNRVIFVQN CPDTAKKLEK NFSCNVNTDI KDAVVVPVPQ TGANSLPSAE GGPPEVVSV
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