About Polyribonucleotide nucleotidyltransferase 1, mitochondrial
Polyribonucleotide nucleotidyltransferase 1, mitochondrial (PNPT1) is a protein
from Homo sapiens identified by UniProt accession
Q8TCS8, 783 residues long.
MolForge cross-references it against 0 known binders and
145 disease associations.
Target properties
| Protein name | Polyribonucleotide nucleotidyltransferase 1, mitochondrial |
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| UniProt accession | Q8TCS8 |
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| Gene | PNPT1 |
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| Organism | Homo sapiens |
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| Length | 783 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (145)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation defect type 13 · score 0.80
- deafness · score 0.68
- autosomal recessive nonsyndromic hearing loss 70 · score 0.63
- spinocerebellar ataxia type 25 · score 0.62
- genetic disorder · score 0.49
- hearing loss · score 0.46
- hearing loss, autosomal recessive · score 0.37
- Dystonia · score 0.37
- open-angle glaucoma · score 0.35
- hereditary breast ovarian cancer syndrome · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TCS8-F1 | alphafold | PREDICTED | 87.41 | — |
Amino-acid sequence (783 residues)
MAACRYCCSC LRLRPLSDGP FLLPRRDRAL TQLQVRALWS SAGSRAVAVD LGNRKLEISS GKLARFADGS AVVQSGDTAV MVTAVSKTKP SPSQFMPLVV DYRQKAAAAG RIPTNYLRRE IGTSDKEILT SRIIDRSIRP LFPAGYFYDT QVLCNLLAVD GVNEPDVLAI NGASVALSLS DIPWNGPVGA VRIGIIDGEY VVNPTRKEMS SSTLNLVVAG APKSQIVMLE ASAENILQQD FCHAIKVGVK YTQQIIQGIQ QLVKETGVTK RTPQKLFTPS PEIVKYTHKL AMERLYAVFT DYEHDKVSRD EAVNKIRLDT EEQLKEKFPE ADPYEIIESF NVVAKEVFRS IVLNEYKRCD GRDLTSLRNV SCEVDMFKTL HGSALFQRGQ TQVLCTVTFD SLESGIKSDQ VITAINGIKD KNFMLHYEFP PYATNEIGKV TGLNRRELGH GALAEKALYP VIPRDFPFTI RVTSEVLESN GSSSMASACG GSLALMDSGV PISSAVAGVA IGLVTKTDPE KGEIEDYRLL TDILGIEDYN GDMDFKIAGT NKGITALQAD IKLPGIPIKI VMEAIQQASV AKKEILQIMN KTISKPRASR KENGPVVETV QVPLSKRAKF VGPGGYNLKK LQAETGVTIS QVDEETFSVF APTPSAMHEA RDFITEICKD DQEQQLEFGA VYTATITEIR DTGVMVKLYP NMTAVLLHNT QLDQRKIKHP TALGLEVGQE IQVKYFGRDP ADGRMRLSRK VLQSPATTVV RTLNDRSSIV MGEPISQSSS NSQ
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