Ceramide kinase (CERK)

About Ceramide kinase

Ceramide kinase (CERK) is a protein from Homo sapiens identified by UniProt accession Q8TCT0, 537 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.

Target properties

Protein name	Ceramide kinase
UniProt accession	Q8TCT0
Gene	CERK
Organism	Homo sapiens
Length	537 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (115)

Diseases linked to this target (Open Targets).

body height · score 0.41
appendicular lean mass · score 0.40
neurodegenerative disease · score 0.25
neoplasm · score 0.09
triple-negative breast cancer · score 0.08
breast cancer · score 0.06
isolated agammaglobulinemia · score 0.06
autosomal recessive severe congenital neutropenia due to JAGN1 deficiency · score 0.05
X-linked severe congenital neutropenia · score 0.05
immunodeficiency 53 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TCT0-F1	alphafold	PREDICTED	88.42	—

Amino-acid sequence (537 residues)

MGATGAAEPL QSVLWVKQQR CAVSLEPARA LLRWWRSPGP GAGAPGADAC SVPVSEIIAV EETDVHGKHQ GSGKWQKMEK PYAFTVHCVK RARRHRWKWA QVTFWCPEEQ LCHLWLQTLR EMLEKLTSRP KHLLVFINPF GGKGQGKRIY ERKVAPLFTL ASITTDIIVT EHANQAKETL YEINIDKYDG IVCVGGDGMF SEVLHGLIGR TQRSAGVDQN HPRAVLVPSS LRIGIIPAGS TDCVCYSTVG TSDAETSALH IVVGDSLAMD VSSVHHNSTL LRYSVSLLGY GFYGDIIKDS EKKRWLGLAR YDFSGLKTFL SHHCYEGTVS FLPAQHTVGS PRDRKPCRAG CFVCRQSKQQ LEEEQKKALY GLEAAEDVEE WQVVCGKFLA INATNMSCAC RRSPRGLSPA AHLGDGSSDL ILIRKCSRFN FLRFLIRHTN QQDQFDFTFV EVYRVKKFQF TSKHMEDEDS DLKEGGKKRF GHICSSHPSC CCTVSNSSWN CDGEVLHSPA IEVRVHCQLV RLFARGIEEN PKPDSHS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards