About Phosphoethanolamine/phosphocholine phosphatase
Phosphoethanolamine/phosphocholine phosphatase (PHOSPHO1) is a protein
from Homo sapiens identified by UniProt accession
Q8TCT1, 267 residues long.
MolForge cross-references it against 0 known binders and
477 disease associations.
Target properties
| Protein name | Phosphoethanolamine/phosphocholine phosphatase |
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| UniProt accession | Q8TCT1 |
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| Gene | PHOSPHO1 |
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| Organism | Homo sapiens |
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| Length | 267 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (477)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.42
- neurodegenerative disease · score 0.37
- body height · score 0.34
- testosterone measurement · score 0.23
- reticulocyte measurement · score 0.10
- hypertension · score 0.10
- type 1 diabetes mellitus · score 0.09
- refractive error measurement · score 0.09
- asthma · score 0.09
- C-reactive protein measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TCT1-F1 | alphafold | PREDICTED | 91.09 | — |
Amino-acid sequence (267 residues)
MSGCFPVSGL RCLSRDGRMA AQGAPRFLLT FDFDETIVDE NSDDSIVRAA PGQRLPESLR ATYREGFYNE YMQRVFKYLG EQGVRPRDLS AIYEAIPLSP GMSDLLQFVA KQGACFEVIL ISDANTFGVE SSLRAAGHHS LFRRILSNPS GPDARGLLAL RPFHTHSCAR CPANMCKHKV LSDYLRERAH DGVHFERLFY VGDGANDFCP MGLLAGGDVA FPRRGYPMHR LIQEAQKAEP SSFRASVVPW ETAADVRLHL QQVLKSC
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