Signal peptide peptidase-like 3 (SPPL3)

About Signal peptide peptidase-like 3

Signal peptide peptidase-like 3 (SPPL3) is a protein from Homo sapiens identified by UniProt accession Q8TCT6, 384 residues long. MolForge cross-references it against 0 known binders and 129 disease associations.

Target properties

Protein name	Signal peptide peptidase-like 3
UniProt accession	Q8TCT6
Gene	SPPL3
Organism	Homo sapiens
Length	384 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (129)

Diseases linked to this target (Open Targets).

asthma · score 0.40
neurodegenerative disease · score 0.37
eosinophil count · score 0.36
unipolar depression · score 0.35
aspartate aminotransferase measurement · score 0.34
childhood onset asthma · score 0.34
allergic rhinitis · score 0.33
depressive symptom measurement · score 0.33
neutrophil count · score 0.33
mean corpuscular volume · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TCT6-F1	alphafold	PREDICTED	77.85	—

Amino-acid sequence (384 residues)

MAEQTYSWAY SLVDSSQVST FLISILLIVY GSFRSLNMDF ENQDKEKDSN SSSGSFNGNS TNNSIQTIDS TQALFLPIGA SVSLLVMFFF FDSVQVVFTI CTAVLATIAF AFLLLPMCQY LTRPCSPQNK ISFGCCGRFT AAELLSFSLS VMLVLIWVLT GHWLLMDALA MGLCVAMIAF VRLPSLKVSC LLLSGLLIYD VFWVFFSAYI FNSNVMVKVA TQPADNPLDV LSRKLHLGPN VGRDVPRLSL PGKLVFPSST GSHFSMLGIG DIVMPGLLLC FVLRYDNYKK QASGDSCGAP GPANISGRMQ KVSYFHCTLI GYFVGLLTAT VASRIHRAAQ PALLYLVPFT LLPLLTMAYL KGDLRRMWSE PFHSKSSSSR FLEV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards