Signal peptide peptidase-like 2A (SPPL2A)

About Signal peptide peptidase-like 2A

Signal peptide peptidase-like 2A (SPPL2A) is a protein from Homo sapiens identified by UniProt accession Q8TCT8, 520 residues long. MolForge cross-references it against 0 known binders and 265 disease associations.

Target properties

Protein name	Signal peptide peptidase-like 2A
UniProt accession	Q8TCT8
Gene	SPPL2A
Organism	Homo sapiens
Length	520 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (265)

Diseases linked to this target (Open Targets).

hereditary spastic paraplegia · score 0.33
hereditary spastic paraplegia 51 · score 0.33
FEV/FVC ratio · score 0.33
erythrocyte count · score 0.32
sex hormone-binding globulin measurement · score 0.31
red blood cell density measurement · score 0.30
hematocrit · score 0.29
calcium measurement · score 0.28
leukocyte count · score 0.28
serum gamma-glutamyl transferase measurement · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TCT8-F1	alphafold	PREDICTED	79.40	—

Amino-acid sequence (520 residues)

MGPQRRLSPA GAALLWGFLL QLTAAQEAIL HASGNGTTKD YCMLYNPYWT ALPSTLENAT SISLMNLTST PLCNLSDIPP VGIKSKAVVV PWGSCHFLEK ARIAQKGGAE AMLVVNNSVL FPPSGNRSEF PDVKILIAFI SYKDFRDMNQ TLGDNITVKM YSPSWPNFDY TMVVIFVIAV FTVALGGYWS GLVELENLKA VTTEDREMRK KKEEYLTFSP LTVVIFVVIC CVMMVLLYFF YKWLVYVMIA IFCIASAMSL YNCLAALIHK IPYGQCTIAC RGKNMEVRLI FLSGLCIAVA VVWAVFRNED RWAWILQDIL GIAFCLNLIK TLKLPNFKSC VILLGLLLLY DVFFVFITPF ITKNGESIMV ELAAGPFGNN EKLPVVIRVP KLIYFSVMSV CLMPVSILGF GDIIVPGLLI AYCRRFDVQT GSSYIYYVSS TVAYAIGMIL TFVVLVLMKK GQPALLYLVP CTLITASVVA WRRKEMKKFW KGNSYQMMDH LDCATNEENP VISGEQIVQQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards