Signal peptide peptidase (HM13)

About Signal peptide peptidase

Signal peptide peptidase (HM13) is a protein from Homo sapiens identified by UniProt accession Q8TCT9, 377 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.

Target properties

Protein name	Signal peptide peptidase
UniProt accession	Q8TCT9
Gene	HM13
Organism	Homo sapiens
Length	377 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (167)

Diseases linked to this target (Open Targets).

diastolic blood pressure · score 0.30
body mass index · score 0.26
blood protein measurement · score 0.20
high density lipoprotein cholesterol measurement · score 0.20
apolipoprotein A 1 measurement · score 0.17
triglyceride measurement · score 0.12
hepatocellular carcinoma · score 0.09
erythrocyte count · score 0.09
neoplasm · score 0.09
platelet crit · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TCT9-F1	alphafold	PREDICTED	82.41	—

Amino-acid sequence (377 residues)

MDSALSDPHN GSAEAGGPTN STTRPPSTPE GIALAYGSLL LMALLPIFFG ALRSVRCARG KNASDMPETI TSRDAARFPI IASCTLLGLY LFFKIFSQEY INLLLSMYFF VLGILALSHT ISPFMNKFFP ASFPNRQYQL LFTQGSGENK EEIINYEFDT KDLVCLGLSS IVGVWYLLRK HWIANNLFGL AFSLNGVELL HLNNVSTGCI LLGGLFIYDV FWVFGTNVMV TVAKSFEAPI KLVFPQDLLE KGLEANNFAM LGLGDVVIPG IFIALLLRFD ISLKKNTHTY FYTSFAAYIF GLGLTIFIMH IFKHAQPALL YLVPACIGFP VLVALAKGEV TEMFSYEESN PKDPAAVTES KEGTEASASK GLEKKEK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards