Zona pellucida-like domain-containing protein 1…

About Zona pellucida-like domain-containing protein 1

Zona pellucida-like domain-containing protein 1 (ZPLD1) is a protein from Homo sapiens identified by UniProt accession Q8TCW7, 415 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.

Target properties

Protein name	Zona pellucida-like domain-containing protein 1
UniProt accession	Q8TCW7
Gene	ZPLD1
Organism	Homo sapiens
Length	415 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (57)

Diseases linked to this target (Open Targets).

C-reactive protein measurement · score 0.37
multiple sclerosis · score 0.35
aspartate aminotransferase measurement · score 0.34
anxiety disorder · score 0.32
neurodegenerative disease · score 0.30
adolescent idiopathic scoliosis · score 0.30
asthma · score 0.26
triglyceride measurement · score 0.25
cirrhosis of liver · score 0.25
dry age related macular degeneration · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TCW7-F1	alphafold	PREDICTED	77.27	—

Amino-acid sequence (415 residues)

MEQIWLLLLL TIRVLPGSAQ FNGYNCDANL HSRFPAERDI SVYCGVQAIT MKINFCTVLF SGYSETDLAL NGRHGDSHCR GFINNNTFPA VVIFIINLST LEGCGNNLVV STIPGVSAYG NATSVQVGNI SGYIDTPDPP TIISYLPGLL YKFSCSYPLE YLVNNTQLAS SSAAISVREN NGTFVSTLNL LLYNDSTYNQ QLIIPSIGLP LKTKVFAAVQ ATNLDGRWNV LMDYCYTTPS GNPNDDIRYD LFLSCDKDPQ TTVIENGRSQ RGRFSFEVFR FVKHKNQKMS TVFLHCVTKL CRADDCPFLM PICSHRERRD AGRRTTWSPQ SSSGSAVLSA GPIITRSDET PTNNSQLGSP SMPPFQLNAI TSALISGMVI LGVTSFSLLL CSLALLHRKG PTSLVLNGIR NPVFD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Zona pellucida-like domain-containing protein 1 (ZPLD1)