About Rhophilin-1
Rhophilin-1 (RHPN1) is a protein
from Homo sapiens identified by UniProt accession
Q8TCX5, 670 residues long.
MolForge cross-references it against 0 known binders and
145 disease associations.
Target properties
| Protein name | Rhophilin-1 |
|---|
| UniProt accession | Q8TCX5 |
|---|
| Gene | RHPN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 670 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (145)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.25
- medulloblastoma · score 0.10
- hepatocellular carcinoma · score 0.09
- nephrotic syndrome · score 0.08
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.08
- focal segmental glomerulosclerosis · score 0.08
- proteinuria, chronic benign · score 0.08
- head and neck squamous cell carcinoma · score 0.08
- uridine-cytidineuria · score 0.07
- isolated sedoheptulokinase deficiency · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TCX5-F1 | alphafold | PREDICTED | 78.21 | — |
Amino-acid sequence (670 residues)
MILEERPDGA GAGEESPRLQ GCDSLTQIQC GQLQSRRAQI HQQIDKELQM RTGAENLYRA TSNNRVRETV ALELSYVNSN LQLLKEELEE LSGGVDPGRH GSEAVTVPMI PLGLKETKEL DWSTPLKELI SVHFGEDGAS YEAEIRELEA LRQAMRTPSR NESGLELLTA YYNQLCFLDA RFLTPARSLG LFFHWYDSLT GVPAQQRALA FEKGSVLFNI GALHTQIGAR QDRSCTEGAR RAMEAFQRAA GAFSLLRENF SHAPSPDMSA ASLCALEQLM MAQAQECVFE GLSPPASMAP QDCLAQLRLA QEAAQVAAEY RLVHRTMAQP PVHDYVPVSW TALVHVKAEY FRSLAHYHVA MALCDGSPAT EGELPTHEQV FLQPPTSSKP RGPVLPQELE ERRQLGKAHL KRAILGQEEA LRLHALCRVL REVDLLRAVI SQTLQRSLAK YAELDREDDF CEAAEAPDIQ PKTHQKPEAR MPRLSQGKGP DIFHRLGPLS VFSAKNRWRL VGPVHLTRGE GGFGLTLRGD SPVLIAAVIP GSQAAAAGLK EGDYIVSVNG QPCRWWRHAE VVTELKAAGE AGASLQVVSL LPSSRLPSLG DRRPVLLGPR GLLRSQREHG CKTPASTWAS PRPLLNWSRK AQQGKTGGCP QPCAPVKPAP PSSLKHPGWP
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