About Up-regulator of cell proliferation
Up-regulator of cell proliferation (URGCP) is a protein
from Homo sapiens identified by UniProt accession
Q8TCY9, 931 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | Up-regulator of cell proliferation |
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| UniProt accession | Q8TCY9 |
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| Gene | URGCP |
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| Organism | Homo sapiens |
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| Length | 931 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (36)
Diseases linked to this target (Open Targets).
- vitamin D measurement · score 0.18
- reticulocyte count · score 0.13
- neoplasm · score 0.10
- hepatocellular carcinoma · score 0.10
- non-small cell lung carcinoma · score 0.08
- urinary bladder carcinoma · score 0.08
- mean platelet volume · score 0.07
- reticulocyte measurement · score 0.06
- osteosarcoma · score 0.06
- colon adenocarcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TCY9-F1 | alphafold | PREDICTED | 76.43 | — |
Amino-acid sequence (931 residues)
MASPGIEVEL LGKGHSDLGE VAPEIKASER RTAVAIADLE WREMEGDDCE FRYGDGTNEA QDNDFPTVER SRLQEMLSLL GLETYQVQKL SLQDSLQISF DSMKNWAPQV PKDLPWNFLR KLQALNADAR NTTMVLDVLP DARPVEKESQ MEEEIIYWDP ADDLAADIYS FSELPTPDTP VNPLDLLCAL LLSSDSFLQQ EIALKMALCQ FALPLVLPDS ENHYHTFLLW AMRGIVRTWW SQPPRGMGSF REDSVVLSRA PAFAFVRMDV SSNSKSQLLN AVLSPGHRQW DCFWHRDLNL GTNAREISDG LVEISWFFPS GREDLDIFPE PVAFLNLRGD IGSHWLQFKL LTEISSAVFI LTDNISKKEY KLLYSMKEST TKYYFILSPY RGKRNTNLRF LNKLIPVLKI DHSHVLVKVS STDSDSFVKR IRAIVGNVLR APCRRVSVED MAHAARKLGL KVDEDCEECQ KAKDRMERIT RKIKDSDAYR RDELRLQGDP WRKAAQVEKE FCQLQWAVDP PEKHRAELRR RLLELRMQQN GHDPSSGVQE FISGISSPSL SEKQYFLRWM EWGLARVAQP RLRQPPETLL TLRPKHGGTT DVGEPLWPEP LGVEHFLREM GQFYEAESCL VEAGRLPAGQ RRFAHFPGLA SELLLTGLPL ELIDGSTLSM PVRWVTGLLK ELHVRLERRS RLVVLSTVGV PGTGKSTLLN TMFGLRFATG KSCGPRGAFM QLITVAEGFS QDLGCDHILV IDSGGLIGGA LTSAGDRFEL EASLATLLMG LSNVTVISLA ETKDIPAAIL HAFLRLEKTG HMPNYQFVYQ NLHDVSVPGP RPRDKRQLLD PPGDLSRAAA QMEKQGDGFR ALAGLAFCDP EKQHIWHIPG LWHGAPPMAA VSLAYSEAIF ELKRCLLENI RNGLSNQNKN IQQLIELVRR L
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