Anterior gradient protein 3 (AGR3)

About Anterior gradient protein 3

Anterior gradient protein 3 (AGR3) is a protein from Homo sapiens identified by UniProt accession Q8TD06, 166 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.

Target properties

Protein name	Anterior gradient protein 3
UniProt accession	Q8TD06
Gene	AGR3
Organism	Homo sapiens
Length	166 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (120)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.25
PHF-tau measurement · score 0.23
neoplasm · score 0.10
breast cancer · score 0.09
coffee consumption · score 0.08
coffee consumption measurement · score 0.07
Barrett's esophagus · score 0.07
cancer · score 0.07
urinary albumin to creatinine ratio · score 0.07
caffeine metabolite measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TD06-F1	alphafold	PREDICTED	88.66	—

Amino-acid sequence (166 residues)

MMLHSALGLC LLLVTVSSNL AIAIKKEKRP PQTLSRGWGD DITWVQTYEE GLFYAQKSKK PLMVIHHLED CQYSQALKKV FAQNEEIQEM AQNKFIMLNL MHETTDKNLS PDGQYVPRIM FVDPSLTVRA DIAGRYSNRL YTYEPRDLPL LIENMKKALR LIQSEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards