Protein bicaudal D homolog 2 (BICD2)

About Protein bicaudal D homolog 2

Protein bicaudal D homolog 2 (BICD2) is a protein from Homo sapiens identified by UniProt accession Q8TD16, 824 residues long. MolForge cross-references it against 0 known binders and 166 disease associations.

Target properties

Protein name	Protein bicaudal D homolog 2
UniProt accession	Q8TD16
Gene	BICD2
Organism	Homo sapiens
Length	824 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (166)

Diseases linked to this target (Open Targets).

autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures · score 0.80
spinal muscular atrophy, lower extremity-predominant, 2B, prenatal onset, autosomal dominant · score 0.73
autosomal dominant childhood-onset proximal spinal muscular atrophy · score 0.55
genetic disorder · score 0.48
neuronopathy, distal hereditary motor, autosomal dominant · score 0.46
arthrogryposis multiplex congenita · score 0.44
Decreased fetal movement · score 0.44
Spastic paraplegia · score 0.38
hydrops fetalis · score 0.37
pterygium · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TD16-F1	alphafold	PREDICTED	78.01	—

Amino-acid sequence (824 residues)

MSAPSEEEEY ARLVMEAQPE WLRAEVKRLS HELAETTREK IQAAEYGLAV LEEKHQLKLQ FEELEVDYEA IRSEMEQLKE AFGQAHTNHK KVAADGESRE ESLIQESASK EQYYVRKVLE LQTELKQLRN VLTNTQSENE RLASVAQELK EINQNVEIQR GRLRDDIKEY KFREARLLQD YSELEEENIS LQKQVSVLRQ NQVEFEGLKH EIKRLEEETE YLNSQLEDAI RLKEISERQL EEALETLKTE REQKNSLRKE LSHYMSINDS FYTSHLHVSL DGLKFSDDAA EPNNDAEALV NGFEHGGLAK LPLDNKTSTP KKEGLAPPSP SLVSDLLSEL NISEIQKLKQ QLMQMEREKA GLLATLQDTQ KQLEHTRGSL SEQQEKVTRL TENLSALRRL QASKERQTAL DNEKDRDSHE DGDYYEVDIN GPEILACKYH VAVAEAGELR EQLKALRSTH EAREAQHAEE KGRYEAEGQA LTEKVSLLEK ASRQDRELLA RLEKELKKVS DVAGETQGSL SVAQDELVTF SEELANLYHH VCMCNNETPN RVMLDYYREG QGGAGRTSPG GRTSPEARGR RSPILLPKGL LAPEAGRADG GTGDSSPSPG SSLPSPLSDP RREPMNIYNL IAIIRDQIKH LQAAVDRTTE LSRQRIASQE LGPAVDKDKE ALMEEILKLK SLLSTKREQI TTLRTVLKAN KQTAEVALAN LKSKYENEKA MVTETMMKLR NELKALKEDA ATFSSLRAMF ATRCDEYITQ LDEMQRQLAA AEDEKKTLNS LLRMAIQQKL ALTQRLELLE LDHEQTRRGR AKAAPKTKPA TPSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards