About Zinc finger protein 398
Zinc finger protein 398 (ZNF398) is a protein
from Homo sapiens identified by UniProt accession
Q8TD17, 642 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Zinc finger protein 398 |
|---|
| UniProt accession | Q8TD17 |
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| Gene | ZNF398 |
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| Organism | Homo sapiens |
|---|
| Length | 642 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (38)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.42
- neutrophil count · score 0.41
- leukocyte count · score 0.36
- neutrophil percentage of leukocytes · score 0.35
- myeloid white cell count · score 0.34
- neuroimaging measurement · score 0.26
- brain volume measurement · score 0.26
- eosinophil percentage of leukocytes · score 0.26
- neutrophil percentage of granulocytes · score 0.26
- eosinophil percentage of granulocytes · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TD17-F1 | alphafold | PREDICTED | 59.91 | — |
Amino-acid sequence (642 residues)
MAEAAPAPTS EWDSECLTSL QPLPLPTPPA ANEAHLQTAA ISLWTVVAAV QAIERKVEIH SRRLLHLEGR TGTAEKKLAS CEKTVTELGN QLEGKWAVLG TLLQEYGLLQ RRLENLENLL RNRNFWILRL PPGIKGDIPK VPVAFDDVSI YFSTPEWEKL EEWQKELYKN IMKGNYESLI SMDYAINQPD VLSQIQPEGE HNTEDQAGPE ESEIPTDPSE EPGISTSDIL SWIKQEEEPQ VGAPPESKES DVYKSTYADE ELVIKAEGLA RSSLCPEVPV PFSSPPAAAK DAFSDVAFKS QQSTSMTPFG RPATDLPEAS EGQVTFTQLG SYPLPPPVGE QVFSCHHCGK NLSQDMLLTH QCSHATEHPL PCAQCPKHFT PQADLSSTSQ DHASETPPTC PHCARTFTHP SRLTYHLRVH NSTERPFPCP DCPKRFADQA RLTSHRRAHA SERPFRCAQC GRSFSLKISL LLHQRGHAQE RPFSCPQCGI DFNGHSALIR HQMIHTGERP YPCTDCSKSF MRKEHLLNHR RLHTGERPFS CPHCGKSFIR KHHLMKHQRI HTGERPYPCS YCGRSFRYKQ TLKDHLRSGH NGGCGGDSDP SGQPPNPPGP LITGLETSGL GVNTEGLETN QWYGEGSGGG VL
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