About Sideroflexin-5
Sideroflexin-5 (SFXN5) is a protein
from Homo sapiens identified by UniProt accession
Q8TD22, 340 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Sideroflexin-5 |
|---|
| UniProt accession | Q8TD22 |
|---|
| Gene | SFXN5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 340 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (25)
Diseases linked to this target (Open Targets).
- parental genotype effect measurement · score 0.26
- fatty acid measurement · score 0.26
- breast milk measurement · score 0.26
- schizophrenia · score 0.20
- self reported educational attainment · score 0.20
- intelligence · score 0.20
- bone density · score 0.16
- drug use measurement · score 0.13
- urinary metabolite measurement · score 0.04
- exercise-induced hyperinsulinism · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TD22-F1 | alphafold | PREDICTED | 88.58 | — |
Amino-acid sequence (340 residues)
MADTATTASA AAASAASASS DAPPFQLGKP RFQQTSFYGR FRHFLDIIDP RTLFVTERRL REAVQLLEDY KHGTLRPGVT NEQLWSAQKI KQAILHPDTN EKIFMPFRMS GYIPFGTPIV VGLLLPNQTL ASTVFWQWLN QSHNACVNYA NRNATKPSPA SKFIQGYLGA VISAVSIAVG LNVLVQKANK FTPATRLLIQ RFVPFPAVAS ANICNVVLMR YGELEEGIDV LDSDGNLVGS SKIAARHALL ETALTRVVLP MPILVLPPIV MSMLEKTALL QARPRLLLPV QSLVCLAAFG LALPLAISLF PQMSEIETSQ LEPEIAQATS SRTVVYNKGL
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