About Alanine aminotransferase 2
Alanine aminotransferase 2 (GPT2) is a protein
from Homo sapiens identified by UniProt accession
Q8TD30, 523 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | Alanine aminotransferase 2 |
|---|
| UniProt accession | Q8TD30 |
|---|
| Gene | GPT2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 523 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (117)
Diseases linked to this target (Open Targets).
- glutamate pyruvate transaminase 2 deficiency · score 0.74
- neurodegenerative disease · score 0.46
- genetic disorder · score 0.45
- Intellectual disability · score 0.27
- hereditary spastic paraplegia 73 · score 0.27
- Rare genetic intellectual disability · score 0.26
- Neurodevelopmental disorder · score 0.11
- Intellectual disability, mild · score 0.11
- aggressive behavior · score 0.11
- Delayed speech and language development · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TD30-F1 | alphafold | PREDICTED | 91.60 | — |
Amino-acid sequence (523 residues)
MQRAAALVRR GCGPRTPSSW GRSQSSAAAE ASAVLKVRPE RSRRERILTL ESMNPQVKAV EYAVRGPIVL KAGEIELELQ RGIKKPFTEV IRANIGDAQA MGQQPITFLR QVMALCTYPN LLDSPSFPED AKKRARRILQ ACGGNSLGSY SASQGVNCIR EDVAAYITRR DGGVPADPDN IYLTTGASDG ISTILKILVS GGGKSRTGVM IPIPQYPLYS AVISELDAIQ VNYYLDEENC WALNVNELRR AVQEAKDHCD PKVLCIINPG NPTGQVQSRK CIEDVIHFAW EEKLFLLADE VYQDNVYSPD CRFHSFKKVL YEMGPEYSSN VELASFHSTS KGYMGECGYR GGYMEVINLH PEIKGQLVKL LSVRLCPPVS GQAAMDIVVN PPVAGEESFE QFSREKESVL GNLAKKAKLT EDLFNQVPGI HCNPLQGAMY AFPRIFIPAK AVEAAQAHQM APDMFYCMKL LEETGICVVP GSGFGQREGT YHFRMTILPP VEKLKTVLQK VKDFHINFLE KYA
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