About Coiled-coil alpha-helical rod protein 1
Coiled-coil alpha-helical rod protein 1 (CCHCR1) is a protein
from Homo sapiens identified by UniProt accession
Q8TD31, 782 residues long.
MolForge cross-references it against 0 known binders and
196 disease associations.
Target properties
| Protein name | Coiled-coil alpha-helical rod protein 1 |
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| UniProt accession | Q8TD31 |
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| Gene | CCHCR1 |
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| Organism | Homo sapiens |
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| Length | 782 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (196)
Diseases linked to this target (Open Targets).
- allergic rhinitis · score 0.22
- Eczematoid dermatitis · score 0.22
- type 2 diabetes mellitus · score 0.19
- response to reverse transcriptase inhibitor · score 0.19
- prostate carcinoma · score 0.18
- blood protein measurement · score 0.17
- multiple myeloma · score 0.16
- psoriasis · score 0.14
- COVID-19 · score 0.14
- thyroid stimulating hormone measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TD31-F1 | alphafold | PREDICTED | 79.10 | — |
Amino-acid sequence (782 residues)
MFPPSGSTGL IPPSHFQARP LSTLPRMAPT WLSDIPLVQP PGHQDVSERR LDTQRPQVTM WERDVSSDRQ EPGRRGRSWG LEGSQALSQQ AEVIVRQLQE LRRLEEEVRL LRETSLQQKM RLEAQAMELE ALARAEKAGR AEAEGLRAAL AGAEVVRKNL EEGSQRELEE VQRLHQEQLS SLTQAHEEAL SSLTSKAEGL EKSLSSLETR RAGEAKELAE AQREAELLRK QLSKTQEDLE AQVTLVENLR KYVGEQVPSE VHSQTWELER QKLLETMQHL QEDRDSLHAT AELLQVRVQS LTHILALQEE ELTRKVQPSD SLEPEFTRKC QSLLNRWREK VFALMVQLKA QELEHSDSVK QLKGQVASLQ EKVTSQSQEQ AILQRSLQDK AAEVEVERMG AKGLQLELSR AQEARRRWQQ QTASAEEQLR LVVNAVSSSQ IWLETTMAKV EGAAAQLPSL NNRLSYAVRK VHTIRGLIAR KLALAQLRQE SCPLPPPVTD VSLELQQLRE ERNRLDAELQ LSARLIQQEV GRAREQGEAE RQQLSKVAQQ LEQELQQTQE SLASLGLQLE VARQGQQEST EEAASLRQEL TQQQELYGQA LQEKVAEVET RLREQLSDTE RRLNEARREH AKAVVSLRQI QRRAAQEKER SQELRRLQEE ARKEEGQRLA RRLQELERDK NLMLATLQQE GLLSRYKQQR LLTVLPSLLD KKKSVVSSPR PPECSASAPV AAAVPTRESI KGSLSVLLDD LQDLSEAISK EEAVCQGDNL DRCSSSNPQM SS
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