About Protein LKAAEAR1
Protein LKAAEAR1 (LKAAEAR1) is a protein
from Homo sapiens identified by UniProt accession
Q8TD35, 194 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | Protein LKAAEAR1 |
|---|
| UniProt accession | Q8TD35 |
|---|
| Gene | LKAAEAR1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 194 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (95)
Diseases linked to this target (Open Targets).
- vital capacity · score 0.25
- response to statin · score 0.13
- mean corpuscular volume · score 0.11
- essential tremor · score 0.09
- peak expiratory flow · score 0.08
- mathematical ability · score 0.07
- Young adult-onset Parkinsonism · score 0.07
- Hereditary late-onset Parkinson disease · score 0.07
- X-linked dystonia-parkinsonism · score 0.06
- Cranio-cervical dystonia with laryngeal and upper-limb involvement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TD35-F1 | alphafold | PREDICTED | 71.01 | — |
Amino-acid sequence (194 residues)
MPPPAKEGGR KGPRERSGKS APGTAQGEER AKGAPATEPP KPGWALTPQG LAAMLPAQRH RHLLFGDLLE DVGAAASTFP CGSVEPGYRM PDPRPWTQSL ELPAERQNRL LGVLKAAEAR GRVRALRLRY TRMRAEEIAL LIQRQKSARA AIRLELFLPP QLKPARIPDP LDRQERRRVE TILEENVDGT IFPR
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