About Pleckstrin homology domain-containing family O member 2
Pleckstrin homology domain-containing family O member 2 (PLEKHO2) is a protein
from Homo sapiens identified by UniProt accession
Q8TD55, 490 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Pleckstrin homology domain-containing family O member 2 |
|---|
| UniProt accession | Q8TD55 |
|---|
| Gene | PLEKHO2 |
|---|
| Organism | Homo sapiens |
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| Length | 490 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (30)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- platelet component distribution width · score 0.39
- hypertrophic cardiomyopathy · score 0.28
- platelet count · score 0.26
- FEV/FVC ratio · score 0.21
- HbA1c measurement · score 0.15
- mean platelet volume · score 0.15
- platelet crit · score 0.15
- pulse pressure measurement · score 0.13
- inflammatory bowel disease · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TD55-F1 | alphafold | PREDICTED | 62.24 | — |
Amino-acid sequence (490 residues)
MEEEGVKEAG EKPRGAQMVD KAGWIKKSSG GLLGFWKDRY LLLCQAQLLV YENEDDQKCV ETVELGSYEK CQDLRALLKR KHRFILLRSP GNKVSDIKFQ APTGEEKESW IKALNEGINR GKNKAFDEVK VDKSCALEHV TRDRVRGGQR RRPPTRVHLK EVASAASDGL LRLDLDVPDS GPPVFAPSNH VSEAQPRETP RPLMPPTKPF LAPETTSPGD RVETPVGERA PTPVSASSEV SPESQEDSET PAEEDSGSEQ PPNSVLPDKL KVSWENPSPQ EAPAAESAEP SQAPCSETSE AAPREGGKPP TPPPKILSEK LKASMGEMQA SGPPAPGTVQ VSVNGMDDSP EPAKPSQAEG TPGTPPKDAT TSTALPPWDL PPQFHPRCSS LGDLLGEGPR HPLQPRERLY RAQLEVKVAS EQTEKLLNKV LGSEPAPVSA ETLLSQAVEQ LRQATQVLQE MRDLGELSQE APGLREKRKE LVTLYRRSAP
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