About Melanoma-associated antigen C3
Melanoma-associated antigen C3 (MAGEC3) is a protein
from Homo sapiens identified by UniProt accession
Q8TD91, 643 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Target properties
| Protein name | Melanoma-associated antigen C3 |
|---|
| UniProt accession | Q8TD91 |
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| Gene | MAGEC3 |
|---|
| Organism | Homo sapiens |
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| Length | 643 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (14)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.08
- esophageal squamous cell carcinoma · score 0.07
- cancer · score 0.02
- anti-neutrophil antibody associated vasculitis · score 0.02
- Laurence-Moon syndrome · score 0.02
- non-small cell lung carcinoma · score 0.01
- ovarian carcinoma · score 0.01
- ovarian neoplasm · score 0.00
- melanoma · score 0.00
- hepatocellular carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TD91-F1 | alphafold | PREDICTED | 43.38 | — |
Amino-acid sequence (643 residues)
MLLPCHWVLD ATFSDGSLGQ WVKNTCATYA LSPVVLPPQP QPRKKATDKD YSAFHLGHLR EVRLFLRGGT SDQRMDSLVL CPTYFKLWRT LSGSPGLQLS DLHFGSQPEG KFSLRRAVSV KQREEPQDWP LNEKRTLWKD SDLPTWRRGT GYTLSLPAVS PGKRLWGEKA GSLPESEPLF TYTLDEKVDK LVQFLLLKYQ AKEPLTRAEM QMNVINTYTG YFPMIFRKAR EFIEILFGIS LTEVDPDHFY VFVNTLDLTC EGSLSDEQGM PQNRLLILIL SVIFIKGNCA SEEVIWEVLN AIGPWSALAG FADVLSRLAL WESEGPEAFC EESGLRSAEG SVLDLANPQG LAGHRQEDGR RGLTEASPQQ KKGGEDEDMP AAGMPPLPQS PPEIPPQGPP KISPQGPPQS PPQSPLDSCS SPLLWTRLDE ESSSEEEDTA TWHALPESES LPRYALDEKV AELVQFLLLK YQTKEPVTKA EMLTTVIKKY KDYFPMIFGK AHEFIELIFG IALTDMDPDN HSYFFEDTLD LTYEGSLIDD QGMPKNCLLI LILSMIFIKG SCVPEEVIWE VLSAIGPIQR PAREVLEFLS KLSSIIPSAF PSWYMDALKD MEDRAQAIID TTDDATAMAS ASPSVMSTNF CPE
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